Activation and protection

Two complementary actions, one molecule.

ch-OSA® does not provide collagen. It activates the enzymes that synthesize it, and supports the metabolic pathway that protects existing fibers from disruption.

Two complementary actions, one molecule.

The two pathways

The two actions are complementary, and distinguish ch-OSA® from collagen peptide or single-cofactor supplementation.

ch-OSA® one molecule
Pathway 1

Activation

Ornithine aminotransferaseProlyl hydroxylaseLysyl hydroxylaseLysyl oxidase
  1. ch-OSA® delivers bioavailable monomeric silicon
  2. The four enzymes are activated
  3. Proline is converted into hydroxyproline
  4. Collagen fibers are cross-linked into a stable structure

Builds new collagen with structural integrity

Pathway 2

Protection

CholineHomocysteine metabolismEFSA-validated
  1. Choline contributes to normal homocysteine metabolism
  2. Homocysteine is a factor known to disrupt collagen cross-linking
  3. By supporting this pathway, ch-OSA® limits that disruption
  4. Existing collagen structures are preserved over time

Protects the integrity of existing collagen

Collagen peptides supply material the body may or may not assemble. ch-OSA® activates the enzymes that build collagen and protects the fibers you already have.

See the clinical evidence
The clinical gap

Where post-operative biology is left unsupported

From dental surgery to dermatology and aesthetic procedures, clinical outcomes depend on collagen synthesis and tissue quality that current protocols rarely address.

  • Documented support across dentistry, dermatology and connective tissue health
  • Six peer-reviewed clinical studies on the underlying biology
  • A protocol-grade adjunctive approach, prescription-only
  • Practitioner-controlled integration into your existing pathway
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Where post-operative biology is left unsupported

Get the practitioner integration kit

Everything you need to integrate Biosil® into your clinical pathway, from protocol guide to patient information.

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Clinical evidence

ch-OSA® across multiple medical fields

Peer-reviewed studies across dentistry, dermatology and connective tissue health. Free access for healthcare professionals.

Anti-ageing effects of oral ch-OSA® on hair, skin and nails
Open-labelInterventional
DermatologyInt J Res Dermatol., 2020

Anti-ageing effects of oral ch-OSA® on hair, skin and nails

Oral ch-OSA® showed significant beneficial effects on hair, skin and nails with good tolerability.

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The effect of ch-OSA® in patients with peri-implantitis
Double-blind RCTPlacebo-controlled12 months
DentistryBMC Oral Health, 2021

The effect of ch-OSA® in patients with peri-implantitis

Improved gum recession and stabilization of bone loss at peri-implantitis sites vs placebo after 12 months.

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Choline-stabilized orthosilicic acid: applications of an oral supplement in dermatology
Review
DermatologyJ Plastic & Pathology Dermatology, 2023

Choline-stabilized orthosilicic acid: applications of an oral supplement in dermatology

Several clinical studies report positive anti-ageing effects of ch-OSA® on skin, hair and nails.

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Effect of oral ch-OSA® on hair tensile strength and morphology in women with fine hair
Double-blind RCTPlacebo-controlled
HairArch Dermatol Res, 2007

Effect of oral ch-OSA® on hair tensile strength and morphology in women with fine hair

ch-OSA® helps reduce loss in hair elasticity and strength and improves hair thickness.

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ch-OSA® in patients with symptomatic knee osteoarthritis
Double-blind RCTMulticenter12 weeks
Bone & jointBMC Musculoskeletal Disorders, 2008

ch-OSA® in patients with symptomatic knee osteoarthritis

ch-OSA® reduced symptoms of knee OA, associated with a significant reduction of cartilage-degradation biomarkers.

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ch-OSA® as an adjunct to Calcium/Vitamin D3 stimulates markers of bone formation
Double-blind RCTPlacebo-controlled
Bone & jointBMC Musculoskeletal Disorders, 2008

ch-OSA® as an adjunct to Calcium/Vitamin D3 stimulates markers of bone formation

Combined ch-OSA® with Ca/VitD3 has a beneficial effect on bone turnover, especially on bone collagen.

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